Effects of aerobic exercise on health outcomes and quality of health in people living with HIV on antiretroviral therapy

Abstract

HIV remains a global major public health issue and the cases in developing countries are so high. Antiretroviral Therapy (ART) plays a big role in reducing the morbidity and mortality among the people living with HIV (PLHIV). The ART is associated with long-term side effects including an increased risk of Non-Communicable Diseases (NCDs) such as cardiovascular disease, diabetes, and metabolic syndrome. These complications negatively impact the quality of life of PLHIV, necessitating holistic approaches to care. While ART controls viral replication, complementary strategies, including lifestyle interventions like exercise, are essential to mitigate NCDs. Exercise, particularly aerobic and resistance training, has been shown to improve cardiovascular health, metabolic function, and psychological well-being in PLHIV. Specific exercises such as walking, jogging, cycling, swimming, and weight training can help manage NCDs effectively when tailored to an individual’s fitness level and health needs. Supervised exercise programs, led by professionals such as clinical exercise physiologists, are critical to ensure safety, optimize benefits, and encourage adherence. These programs could be integrated into HIV care to provide structured and effective interventions. In limited resource countries, access to exercise facilities, and a lack of trained professionals present significant barriers to implementing exercise programs for PLHIV. Additionally, cultural misconceptions and a lack of awareness about the role of exercise in health management hinder uptake. However, from the reviewed papers, research gaps exist regarding context-specific exercise protocols, the long-term benefits of supervised exercise, and how to best implement these programs in resource-limited settings. In conclusion, structured exercise programs hold great potential to improve health outcomes and quality of life for PLHIV on ART. Addressing existing barriers and conducting further research are essential to maximize the impact of exercise as a tool for managing NCDs in this population.