Prevalence and predictors of stress, anxiety, and depression among healthcare workers during the COVID–19 pandemic at a mental referral hospital in Kampala, Uganda
Date
2025-08-08
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Public Health
Abstract
Background
Healthcare workers faced immense psychological strain during the Corona Virus Disease 2019 (COVID – 19) pandemic due to increased workloads, infection risk, and limited protective equipment. This study assessed the prevalence of stress, anxiety, and depression among them and identified factors contributing to these mental health challenges during the outbreak.
Methods
A cross-sectional study was done at Butabika National Mental Referral Hospital between February and March of 2023. We gave self-administered, paper-based surveys to all willing Healthcare workers (HCWs) working day shifts during this period. Sections on socio-demographics characteristics, perceived stress (PSS–10), anxiety (GAD–7), and depression (PHQ–9) were all included in the questionnaire. The SPSS version 26.0 program was used to analyse the data. To determine the variables that predict psychological distress, we employed Modified Poisson regression. When the p-value was less than 0.05, statistical significance was declared.
Results
Among the 209 enrolled participants, 198 (94.7%) eligible subjects were included in the analysis. Majority of the participants (58.6%) were female, (73.7%) were married, (49.5%) were nurses and 58.6% had more working hours. The prevalence of symptoms of stress, anxiety and depression in healthcare workers during the COVID-19 pandemic was 91.9%, 27.3% and 57.6%, respectively. In relation to perceived stress, being female (aRR = 1.219; 95% CI: 1.010–2.922), being younger in age (aRR = 1.672; 95% CI: 1.050–5.733) and having worked for 11–15 years (aRR = 1.274; 95% CI: 1.020–2.503) were significantly associated with higher risk of perceived stress. Participants with a bachelor’s degree had higher risk of generalized anxiety disorder symptoms (aRR = 2.577; 95% CI: 1.123–4.980), whereas being a nurse (aRR = 0.082; 95% CI: 0.040–0.900) showed lower risk of anxiety. Being married (aRR = 1.322; 95% CI: 1.042–2.260) and being younger in age (aRR = 1.037; 95% CI: 1.005–2.834) were significantly associated with higher risk of depressive symptoms, whereas being a technician (aRR = 0.683; 95% CI: 0.480–0.972) and having no change in work volume (aRR = 0.711; 95% CI: 0.532–0.987) were associated to lower risk of depression symptoms.
Conclusion
Psychological distress was high among mental health workers during COVID-19. Supportive measures such as adequate PPE, manageable workloads, mental health check-ins, and challenging societal stigma are needed to improve well-being, within study limitations.
Description
13 p.
Keywords
COVID – 19, Healthcare workers, Anxiety, Depression, Stress, Pandemic, Uganda
Citation
Otai, J...et al.(2025). Prevalence and predictors of stress, anxiety, and depression among healthcare workers during the COVID–19 pandemic at a mental referral hospital in Kampala, Uganda. BMC Public Health 25, 3386 . https://doi.org/10.1186/s12889-025-24233-7