The status of occult HBV infection in a high endemic region : risk of community HBV transmission and reactivation

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dc.contributor.authorKafeero, Hussein Mukasa
dc.contributor.authorOcama, Ponsiano
dc.contributor.authorNdagire, Dorothy
dc.contributor.authorWalusansa, Abdul
dc.contributor.authorNamusoke, Mariam
dc.contributor.authorKudamba, Ali
dc.contributor.authorMuwanda, Fahad
dc.contributor.authorSendagire, Hakim
dc.date.accessioned2025-07-07T06:45:35Z
dc.date.available2025-07-07T06:45:35Z
dc.date.issued2025-06-01
dc.description7 p. : maps
dc.description.abstractObjectives Occult hepatitis B virus (OBI) infection, characterized by the presence of HBV DNA in the absence of detectable HBsAg in the blood, is considered a potential hidden pathway for HBV transmission and reactivation, which can lead to liver cancer. This study aimed to assess the prevalence of OBI in a region of Uganda with high HBV endemicity, in order to help explain variations in HBV distribution within the country. Results Among the 387 participants who tested negative for HBsAg, the majority were women (240 individuals, 62.0%), married (242 individuals, 62.5%), and aged 30 years or older (207 individuals, 53.5%). The OBI was detected in 21 participants (5.43%). Most of those with OBI were 30 years old or younger (13 individuals, 61.9%), male (12 individuals, 57.1%), had normal liver enzyme levels, and showed an average viral load of 194.4 IU/mL with a standard deviation (SD) of ± 122.05.
dc.identifier.citationKafeero, H.M...et al.(2025) The status of occult HBV infection in a high endemic region: risk of community HBV transmission and reactivation. BMC Res Notes 18, 255. https://doi.org/10.1186/s13104-025-07337-6
dc.identifier.urihttps://doi.org/10.1186/s13104-025-07337-6
dc.identifier.urihttps://hdl.handle.net/20.500.12504/2559
dc.language.isoen
dc.publisherBMC Research Notes
dc.subjectOccult hepatitis B infection
dc.subjectLatency
dc.subjectReactivation
dc.subjectImmunocompromised
dc.subjectEndemicity
dc.titleThe status of occult HBV infection in a high endemic region : risk of community HBV transmission and reactivation
dc.typeArticle

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