Asiimwe, Jacent KamuntuNdegeya, KizitoNambooze, JoweriaNantongo, Veronica2025-12-292025-12-292025-11-18Asiimwe, J. K. eta l. (2025). Determinants of household food security and nutritional status of children 24-59 months in Namutumba District, Busoga Sub-region, Uganda. Journal of Nutritional Science, 14, e81.https://doi.org/10.1017/jns.2025.10052https://hdl.handle.net/20.500.12504/26969 P. :Household food security plays a critical role in determining the nutritional status of children, which in turn impacts their growth and development. This study assessed factors influencing household food security and childhood nutritional status and explored the relationship between these variables in Namutumba District. A total of 299 child-caregiver pairs participated in the study. Data were collected through structured interviews and analyzed, with multi-level mixed effects generalized linear models to examine factors associated with severe household food insecurity and children’s nutritional status. Multilinear regressions were used to evaluate the relationship between severe household food insecurity and child nutritional status. The results revealed that most households (60.2%) were severely food insecure. A double burden of malnutrition was observed, with 28.0% of children stunted and 2.8% overweight or obese. Factors positively associated with improved household food security included secondary-level education (p = 0.011), medium to high wealth percentile (p < 0.001), and the presence of at least one income-earning household member (p = 0.045). Conversely, lack of access to agricultural land, food stocks, and access to treated drinking water were significantly linked to severe food insecurity (p < 0.001). Severe food insecurity was positively associated with wasting (β = 0.81, p = 0.007) and negatively associated with stunting (β = −0.37, p = 0.039). In conclusion, multiple factors influence household food security, and the nutritional status of children aged 24–59 months. A comprehensive, food systems-based approach may be key to addressing malnutrition in Namutumba DistrictenINTERDISCIPLINARY RESEARCH AREAS::ChildrenCaregiversFood securityHouseholdNutritional statusArticle