Tabbisa, NamulindaLei-Lei, BaoJustus, KwetegyekaIvan, GumulaYi-Jia, YanZhi-Long, Chen2023-08-292023-08-292023-08Namulinda, T., Bao, L. L., Kwetegyeka, J., Gumula, I., Yan, Y. J., & Chen, Z. L. (2023). Antibacterial and anticancer activities of green-synthesized silver nanoparticles using Photinia glabra fruit extract. Nanomedicine, (0).https://doi.org/10.2217/nnm-2023-0112https://hdl.handle.net/20.500.12504/1424Aims: We prepared Photinia glabra (PG) aqueous fruit extract, utilized it to synthesize silver nanoparticles (PG-Ag NPs) and evaluated the antibacterial and anticancer activities of the nanoparticles (NPs). Materials & methods: Silver nitrate aqueous solution was reduced to PG-Ag NPs using aqueous PG fruit extract. NP shape, size, composition and functionalization were determined using transmission electron microscopy, x-ray photoelectron spectroscopy, Fourier transform infrared and x-ray diffraction. Results & conclusions: PG-Ag NPs were spherical, approximately 39–77 nm-sized, functionalized surfaces with notable antibacterial activity against both Escherichia coli and Staphylococcus aureus, with an MIC <30 ug/ml and cytotoxicity toward esophageal cancer cells, with IC50 values less than 20 ug/ml. PG-Ag@rt NPs have been shown to be a potent antibacterial and anticancer agent, and their enriched particle surfaces can be conjugated with other compounds for multibiomedical applications.enPhotinia glabraAntibacterialAnticancer activitiesAqueous fruit extractArticle