Mwebaze, NicholasNsibambi, Constance Adron NakayizaOjuka, EdwardMaghanga, Mshilla2025-05-162025-05-152025-05-162024-12-31Mwebaze, N., Nsibambi, C. A. N., Ojuka, E. & Maghanga. M., (2024). Twelve Weeks Aerobic Exercise Improves Anxiety and Depression in HIV Positive Clients on Art in Uganda. International Journal of Sport Exercise and Training Sciences - IJSETS, 10(4), 288-298. DOI:10.18826/useeabd.1549248https://doi.org/10.18826/useeabd.1549248https://hdl.handle.net/20.500.12504/2307.2Aim: The study aimed at bridging the gap by assessing the impact of a 12-week aerobic exercise program on anxiety and depression for HIV-positive clients. Methods: The study, conducted at the General Military Hospital in Uganda, employed a quasi-experimental design. Quantitative data was collected using questionnaires and a sample of 135 people living with HIV on antiretroviral therapy engaged in the study. Quantitative data was analyzed using t-tests, revealing significant reductions in depression and anxiety symptoms among participants. Results: The findings demonstrated a 58.5% reduction in depression symptoms and a 72% decrease in anxiety symptoms among participants engaged in aerobic exercises. Both groups exhibited improvements, with the experimental group showing greater reductions. The results further revealed that depression and anxiety are two to four times more common in individuals living with HIV than in those without the virus, and depression is also more common in those on HAART than in those without the virus. Conclusion: The results support the potential of aerobic exercise as a valuable adjunct therapy for people living with HIV on antiretroviral therapy. Well-structured and supervised aerobic exercise was found to be essential for improving the clinical outcomes of PLHIV on ART.enArticle