• Login
    View Item 
    •   KYUSpace | Home
    • Faculty of Science
    • Department of Biological sciences
    • Journal Articles
    • View Item
    •   KYUSpace | Home
    • Faculty of Science
    • Department of Biological sciences
    • Journal Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Mansonella perstans filariasis in Uganda: patterns of microfilaraemia and clinical manifestations in two endemic communities

    Thumbnail
    View/Open
    Santa Maria Asio.pdf (1.770Mb)
    Date
    2009-03-01
    Author
    Asio, Santa Maria
    Simonsen, Paul E.
    Onapa, Ambrose W.
    Metadata
    Show full item record
    Abstract
    Surveys for Mansonella perstans infection and potentially related clinical manifestations were undertaken in two endemic communities in Mukono and Luwero districts of Uganda where no other human filarial infections are transmitted. A sensitive and accurate counting chamber method was used for quantifying microfilaraemia in 100 μl of finger-prick blood. Among 575 and 991 examined individuals aged ≥1 year in the two communities, the overall microfilariae (mf) prevalence was significantly higher in Mukono (76.5%) than in Luwero (57.7%). As early as age 1–4 years, 40.6% and 20.5% of the children were mf-positive. Prevalences increased rapidly with increasing age to reach 89.2% and 81.4% in the 15–19 years age group and then remained high in subsequent age groups. The geometric mean mf intensity among mf-positive individuals was slightly higher in the Mukono community (32.4 mf/100 μl) than in the Luwero community (29.9 mf/100 μl), and this parameter increased with age in both communities. No obvious associations were observed between various clinical parameters and M. perstans microfilaraemia in any of the study communities. The observed patterns of microfilaraemia and the lack of obvious visible clinical manifestations suggest that the host's regulatory responses are downregulated in M. perstans infections. [ClinicalTrials.gov identifier:
    URI
    https://doi.org/10.1016/j.trstmh.2008.08.007
    https://kyuspace.kyu.ac.ug/xmlui/handle/20.500.12504/766
    Collections
    • Journal Articles

    Kyambogo University Copyright © 2015-2022  | University Library | Search Library Catalogue | Contact Us
    KYUSpace Powered By DICTS 
     

     

    Browse

    All of KYUSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Kyambogo University Copyright © 2015-2022  | University Library | Search Library Catalogue | Contact Us
    KYUSpace Powered By DICTS